7 Best Supplements for Blood Sugar Control and Diabetes Management

Do Blood Sugar Support Supplements Work?

The answer to this question cannot be explained by a simple yes or no. Science supports that particular nutrients within supplements act to enhance blood sugar regulation through different action routes, but supplements cannot take the place of medication or lifestyle changes. Let’s take a look at how supplements try to support our health:

• The supplements assist cells by improving the way they react to insulin signals.
• Specific substances delay the rate at which glucose is extracted from the digestive system.
• Enhancing cellular glucose uptake
• Supplementary nutrients have the ability to lessen the inflammation that blocks insulin functionality.
• Provides the body's needs by supporting these processes to properly manage blood sugar.

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The success rates for specific nutrients depend on personal health aspects as well as the particular nutrients under consideration. Individuals who have prediabetes along with type 2 diabetes commonly experience better blood glucose test results by using top-quality nutritional supplements together with appropriate diet plans and exercise routines.

Supplements achieve their most significant results when applied within an entire blood sugar management program instead of functioning alone.

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Did You Know?

• DYK? Berberine may lower A1C as effectively as some first-line meds.
• DYK? Chromium deficiency is more common in people with diabetes.
• DYK? Cinnamon can lower fasting glucose by up to 10%.

Comparison Table

Our Top Picks	WOWMD Blood Sugar Ultra Advanced Formula	WOWMD Berberine Essentials	WOWMD Alpha Lipoic Acid	Maximum Edge GlucoTrust	Glucoberry	Amiclear Drops	Glucofort
Third-party tested	Yes	Yes	Yes	Yes	Yes	No
Highlights	High-strength formula, supports healthy blood sugar and energy levels, vegan, gluten-free, non-GMO, made in the USA in a GMP-certified facility.	Supports healthy blood sugar levels and glucose metabolism, promotes cardiovascular health, and aids in weight management	Powerful antioxidant, supports healthy nerve function, may help improve insulin sensitivity and clinically-studied ingredients, non-GMO, and gluten-free.	Contains 15 herbs and nutrients, promotes restful sleep, reduces cravings, helps convert food to energy and metabolize carbs, fats, and proteins.	Unique approach focused on the "Blood Sugar Drain," formulated with Maqui Berry, Chromium, Biotin, and Gymnema Leaf, manufactured in an FDA-audited facility.	Natural wellness support with a focus on cardiovascular health, formulated with Grape Seed Extract, free from additives for purity.	Supports healthy blood sugar levels and weight management, formulated with Vitamin C, Cinnamon, and Licorice Root, manufactured by Ideal Performance.
Customer Rating	4.8/5	4.8/5	4.7/5	4.7/5	4.8/5	4.7/5	4.7/5
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Key Nutrients in the Best Supplements to Lower Blood Sugar Naturally

The best supplements containing natural blood sugar-lowering compounds include essential nutrients such as:

Berberine:

Berberine stands as the most effective compound found in natural blood sugar-lowering supplements. The plant alkaloid activates the AMPK enzyme to enhance insulin sensitivity while at the same time decreasing liver glucose production.

According to a randomized control trial, berberine matches the ability of certain prescription medications to lower fasting blood glucose and A1C while functioning through different molecular pathways^[2].

"Berberine helps to lower blood glucose by stimulating the activity of genes responsible for activating insulin receptors and through the activation of incretins, which influence insulin release after meals. I recommend berberine to my patients with newly diagnosed type 2 diabetes to reduce blood sugar and potentially prevent the need for pharmaceutical drugs." says, Dr. Mark A. Stengler, N.M.D., M.S., Naturopathic Medical Doctor, and Author of Master of Science Human Biology.

READ MORE: Does Berberine Lower Blood Sugar?

Chromium:

Products that contain chromium function as essential minerals in best A1C-lowering supplements because this mineral strengthens insulin action inside cells. The administration of chromium supplements affects glucose regulation and decreases insulin usage, specifically for people who lack chromium in their bodies.

"Chromium can normalize sugar levels by aiding in the uptake of blood sugar into the body’s cells, where it is used to generate energy more efficiently. It’s also helpful in reducing sweet cravings." ~ says, Dr. Mark Stengler

Studies show that people with type 2 diabetes have lower blood levels of chromium than those without the disease^[3]. The supplement form Chromium picolinate dominates the market because it absorbs better than other forms of the mineral.

Melissa Majumdar, MS, RD, CSOWM, LDN, a registered dietitian and Metabolic & Bariatric Coordinator at Emory University Hospital Midtown, explained in EverydayHealth, said,

“Chromium works with insulin to help your body use blood sugar and may also be involved in the metabolism of carbohydrates, fats, and proteins."

Alpha-Lipoic Acid (ALA):

The compound Alpha-Lipoic Acid (ALA) serves two functions: it works as an antioxidant agent and helps activate enzymes in mitochondria that regulate glucose metabolism. ALA provides two benefits enhanced insulin sensitivity alongside protection against oxidative stress and reduction of diabetic neuropathy symptoms.

As an ingredient, it serves two purposes because it safeguards nerves and stabilizes blood sugar which makes it perfect for inclusion in therapeutic formulations^[4].

"Alpha-lipoic acid is a powerful antioxidant that helps transform blood sugar into energy and can lower blood sugar levels. For diabetic neuropathy, I typically recommend 400 to 500 mg twice daily, but caution is needed when combining it with diabetes medications, as it may cause excessively low blood sugar," says Thomas Kruzel, a naturopathic physician at Rockwood Natural Medicine Clinic in Scottsdale, AZ, and author of The Homeopathic Emergency Guide.

Magnesium:

Agents of magnesium participate in more than 300 cell reactions which also cover glucose-related processes. Insulin performance declines in correlation with reduced magnesium levels which raises the possibility of diabetes development^[5].

"Magnesium helps regulate blood sugar by aiding enzymes involved in insulin signaling and glucose transport," says Kerri Louati, MS, RD, LDN, CDE, integrative and functional dietitian.

Professional values show that dietary supplements optimize both insulin response and blood sugar maintenance particularly for those showing magnesium deficit symptoms.

Bitter Melon Extract:

The compounds present in Bitter Melon Extract replicate insulin functions leading to reduced blood glucose concentrations^[6]. This traditional ingredient contains active elements which activate insulin's cellular mechanisms thus enhancing glucose absorption in peripheral tissues.

Fiber:

The fiber source Inulin as well as Psyllium Husk helps regulate blood sugar, since these fibers delay carbohydrate digestion and reduce their absorption to prevent fast rises in blood glucose levels^[7]. Similarly soluble fibers feed beneficial gut bacteria that can enhance metabolic wellness through the gut-pancreas link.

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Ginseng:

Ginseng, a popular herb in traditional medicine, is well-known for its adaptogenic properties. Ginseng works by improving insulin sensitivity, which can help manage blood glucose levels and prevent spikes.

A 2019 clinical trial on American Ginseng with 24 participants demonstrated that it reduced HbA1c by 0.29% and plasma blood glucose by 12.8 mg/dL, showing its potential for managing Type 2 Diabetes.^[7] Also, the 2024 review found that it may help to decrease post-meal blood sugar in healthy individuals and those with type 2 diabetes.^[8]

Avoid ginseng if you're on immunosuppressants or blood thinners like warfarin, as it may reduce their effectiveness.^[9]

"Red ginseng extract may be a good addition to a natural, broader approach to controlling, limiting, or getting rid of type 2 diabetes. However, it should be used under the supervision of a naturopathic doctor or clinically trained nutritionist, especially for those on multiple medications or with liver or gastrointestinal conditions," says Dr. Andrew Rubman, ND, founder of the Southbury Clinic for Traditional Medicine,

Probiotics:

Probiotics are beneficial bacteria that promote gut health and improve digestion. A healthy gut microbiome can influence how the body responds to insulin and manage glucose levels more effectively.

A 2024 meta-analysis on probiotics involving 507 participants, with 252 in the probiotic group and 255 in the placebo group, revealed significant improvements in blood sugar control and insulin sensitivity in Type 2 Diabetes patients.^[10]

Aloe Vera:

Aloe Vera is more than just a skincare remedy. Its benefits extend to metabolic health, particularly in regulating blood sugar levels. Aloe Vera may help reduce fasting blood sugar in people with prediabetes or type 2 diabetes, and some studies suggest it could be beneficial for people who are looking to manage their blood sugar levels naturally.

This meta-analysis, published in the Journal of Alternative and Complementary Medicine, found that oral aloe vera consumption was associated with significant reductions in fasting blood glucose (FBG) and HbA1c.^[11]

Vitamin D:

Vitamin D plays an essential role in calcium absorption and bone health, but its effects extend beyond the skeletal system. Research has shown that vitamin D deficiency is linked to poor blood sugar control and insulin resistance. Adequate vitamin D levels may improve insulin sensitivity and support overall metabolic health.

A 2025 study on vitamin D supplementation revealed that it enhances insulin sensitivity and glucose metabolism, particularly in individuals with deficiency, underscoring its importance in managing Type 2 Diabetes and reducing associated risks.^[12]

Gymnema:

Gymnema Sylvestre, an herb native to India, has been used in Ayurvedic medicine for centuries to manage blood sugar levels. It works by decreasing the absorption of sugar in the intestines and promoting better insulin function, making it a natural option for those struggling to maintain healthy glucose levels.

A 2021 study on Gymnema sylvestre with 419 individuals reported a significant reduction in fasting blood glucose, postprandial glucose, and HbA1c, confirming its efficacy for blood sugar control in Type 2 Diabetes.^[13]

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The Best Supplements to Lower Blood Sugar and Cholesterol

Image Credit: Best Supplements to Lower Blood Sugar and Cholesterol

Blood sugar and cholesterol follow a direct metabolic connection because any disruption in one greatly impacts the other. Supplements that provide dual blood sugar and cholesterol lowering benefits create the most effective cardiometabolic support for your health.

Omega-3 fatty acids:

Consuming fish oil supplements containing omega-3 fatty acids has three positive effects: it decreases inflammation and makes insulin more sensitive while lowering triglyceride levels. Heart health, together with enhanced glucose metabolism, are two benefits that people gain from taking these healthy fats.

The research indicates a daily intake can lead to beneficial effects for type 2 diabetes patients, along with people who have high blood lipids.^[14]

Niacin:

The cholesterol benefits of niacin (vitamin B3) include higher HDL and decreased LDL and triglycerides levels. High doses of these supplements have a brief impact on elevating blood sugar levels which requires close monitoring. Extended-release medications help minimize the blood sugar effect, yet continue to reduce cholesterol levels.

Cinnamon Extracts:

The external use of cinnamon helps control both lipid levels and blood glucose reactions. Research indicates that the substance increases insulin sensitivity as well as reduces blood sugar levels during fasting and enhances cholesterol levels.^[15]

The water-soluble polyphenols found in the substance duplicate insulin effects, which boost glucose absorption while controlling lipid levels.

ALSO READ: Can Cinnamon Lower Blood Sugar and Manage Diabetes

Best Supplements for Diabetes Type 2: What to Look For

Medical and professional supervision becomes necessary for all patients with type 2 diabetes who consider taking supplements. The most beneficial and best supplements for type 2 diabetes should support medication and lifestyle improvements while targeting different elements of glucose metabolism.

The selection of supplements for type 2 diabetes management requires the following features:

• Complete formulas use several tested ingredients to benefit users
• The quantities of supplements should match the precise dosages utilized in clinical trials.
• Open-source laboratories conduct quality and purity tests on these products.
• Transparent labeling of all ingredients and their amounts
• Minimal fillers, artificial ingredients, or hidden sugars

People with type 2 diabetes may receive positive effects on their glucose metabolism from taking zinc and vitamin D in addition to the previously mentioned nutrients. The insulin storage process depends on zinc, while vitamin D deficiency elevates the chances of developing diabetes.

Supplements need to be used as part of an all-inclusive health method that includes:

• Regular physical activity (both aerobic exercise and resistance training)
• Consuming a proper diet with vegetables together with proteins that are lean and fats that promote health will benefit the body.
• Consistent medication as prescribed by your healthcare provider
• Regular blood glucose monitoring
• Stress management techniques

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Vitamins That Raise Blood Sugar Levels: What to Avoid

Most health supplements work as expected to manage glucose levels, yet there are a few that produce opposite results. Any individual who needs to monitor their glycemic control must know about the vitamins that raise blood sugar levels.

High doses of niacin taken for cholesterol management at 1,000 to 2,000 mg daily usually lead to short-term blood glucose elevation.^[16] The rise occurs depending on dose, while people with glucose regulation difficulties show greater susceptibility to this phenomenon.

Extensive intake of B vitamins such as vitamin B6 and vitamin B12 might modify glucose metabolism if you take more than the established recommended daily intake levels. Medical supervision should always oversee the administration of these vital vitamins because excessive intake can disrupt metabolic operations.

The presence of undetectable sugars along with compounds that modify glucose regulation can be found in selected herbal supplements.

• Licorice root might change cortisol levels activity which could modify blood sugar.
• Adaptogenic herbs could briefly increase blood glucose levels in people who are sensitive to these changes.
• Blends of supplements containing additional sweeteners and fillers tend to introduce carbohydrates that cannot be detected and measured.

Additionally, be cautious with:

• Ginseng products that aren't standardized (effects can vary widely)
• Supplements containing maltodextrin or other high-glycemic fillers
• Proprietary blends that don't disclose specific ingredient amounts

Choosing the Right Blood Sugar Supplement

The important elements people need to evaluate before picking blood sugar supplements include:

• Scientific evidence: Scientific research stands as a key indicator for choosing a supplement when its ingredients show results from clinical trials instead of relying on anecdotal data. The blood glucose management research evidence is strongest for berberine, along with chromium and alpha-lipoic acid.
• Dosage and potency: Most effective blood sugar supplements contain clinically-sanctioned amounts of medicinal components. Research supports the effectiveness of blood glucose management when taking chromium at doses from 200 to 1000 mcg daily and berberine at 1000 to 1500 mg daily as well as ALA at 600 to 1200 mg daily.
• Quality and purity: Select supplements from established manufacturers who practice Good Manufacturing Practices (GMP) and who conduct potency testing and check for contamination. Getting certifications from independent parties will help you confirm the quality of a product.
• Potential interactions: Supplements might respond negatively with diabetes medications together with other substances the patient might take. When taking berberine with metformin it produces enhanced effects which might necessitate healthcare monitoring and possible dose changes with medical supervision.
• Individual health considerations: The selection of blood sugar supplements should base on your individual health situation which involves reviewing kidney function alongside cardiovascular health and current medication prescriptions. Each person requires a different solution since what benefits one person may not suit another person.

Why Trust WOWMD?

WOWMD delivers unbiased, science-backed supplement recommendations through research and expert analysis. We evaluate products based on clinical evidence, ingredient quality, third-party testing, and real consumer feedback, never compromising integrity for promotion.

Meet the Experts

• Melissa Majumdar, MS, RD, CSOWM, LDN, a Registered Dietitian and Metabolic & Bariatric Coordinator at Emory University Hospital Midtown, United States.
• Dr. Mark A. Stengler, N.M.D., M.S., Naturopathic Medical Doctor, and Author of Master of Science Human Biology, United States.
• Dr. Thomas Kruzel, a Naturopathic Physician at Rockwood Natural Medicine Clinic in Scottsdale, AZ, and Author of The Homeopathic Emergency Guide, United States.
• Dr. Andrew Rubman, ND, Founder of the Southbury Clinic for Traditional Medicine, United States.
• Kerri Louati, MS, RD, LDN, CDE, Integrative and Functional Dietitian, United States.