Can You Take Prebiotics and Probiotics Together?
Should you take prebiotics and probiotics together? Explore the science behind microbiome therapy and its potential benefits.
Advertiser Disclosure: WOWMD independently vets all recommended products. If you purchase a featured product, we may be compensated. Learn why you can trust us.

Gut health has been a hot topic lately, and that's totally understandable. A healthy gut does wonders for the body, from the digestive system and mental health to the immune system and skin.
However, discussing what happens in our gut also means discussing what goes into it, like food, drugs and dietary supplements such as prebiotics and probiotics. In the same way we think about different food combinations, it’s also natural to ask, “Can you take prebiotics and probiotics together?”
Continue reading this article to better understand about the prebiotics and probiotics. For example, the way to use them effectively, the potential side effects of using them, and how they can work well together.
Key Takeaways
- Prebiotics feed the good bacteria (probiotics), enhancing their effectiveness in promoting gut health.
- Synbiotic usage of prebiotics and probiotics may aid in healthier digestion and immune.
- Combining prebiotics and probiotics is generally safe, though some may experience minor side effects like gas and bloating.
- Probiotics are best taken with meals, while prebiotics may be better absorbed on an empty stomach or before bedtime.
- For optimal results, it's crucial to take prebiotics and probiotics consistently as directed.
What are Prebiotics and Probiotics?
Prebiotics and probiotics can unite to help support gut flora. But what are prebiotics and probiotics? Can you take prebiotics and probiotics while pregnant? Let’s find out.
A prebiotic is a dietary fiber, usually derived from plants, that supports your digestive system's good bacteria. Probiotics can lead to a diversified and healthy gut microbial community by competing with pathogenic bacteria that produce endotoxins.
Probiotics are either live yeast or bacterial strains. According to Dr March Seabrook of the American Medical Association (AMA), prebiotics are undigestible carbohydrates that are compounds within foods that help good bacteria do even better.
How Prebiotics and Probiotics Work Together
Probiotics and prebiotics can complement each other to support balanced gut health in more ways than one.
Today, functional foods have been developed to improve the gut microbiome with probiotics and prebiotics supplements, and they are generally safe to take together as long as they are taken appropriately.
Here are other vital things to know about prebiotics and probiotics working together:
- Prebiotics may increase the efficiency of probiotics, so try to choose good quality supplements.
- Taking probiotics and prebiotics can help get better results.
- Using probiotics and prebiotics together, known as synbiotic treatment, supports immune system health and help maintain a balanced gut microbiome
Can You Take Prebiotics and Probiotics Together?
A common question around the use of dietary supplements is, “Can you take prebiotics and probiotics at the same time?” and the simple answer is yes.
American Medical Association (AMA) also highlights that maintaining a healthy gut can set patients’ digestive health on the right track. In light of ways to make that happen, March Seabrook, MD, states that "there is also a combination of prebiotics and probiotics—called synbiotics.
But the prebiotics may help nourish the beneficial gut bacteria. Generally, the answer to “When should I take prebiotics and probiotics?” depends on the supplement type and tolerance. Remember that being consistent is the most important thing.
Benefits of Combining Prebiotics and Probiotics
The gut is home to several beneficial and harmful bacteria essential to general health and well-being. Probiotics and prebiotics are supplement types that, when combined, can work together to support one’s gut health by encouraging the growth of good bacteria. In light of this, here are some other benefits that probiotics and prebiotics may provide:
- Together, prebiotics and probiotics can support healthy digestion which may aid in the absorption of nutrients such as vitamins, minerals, and amino acids.
- Probiotics and Prebiotics may also help support a healthy immune system by contributing to a balanced gut microbiome.
Read More: Can You Take A Probiotic With A Multivitamin
How to Take Prebiotics and Probiotics Together
First, it’s best to take probiotics before a meal and cold or with room-temperature water. But can you take prebiotics and probiotics without food? The answer is yes. However, some prebiotics are best absorbed when taken on an empty stomach or a few hours before a meal.
It is possible that probiotics supplements cause gas and bloating, so you may find it more comfortable taking them before bed.
Potential Side Effects and Considerations
Can you take prebiotics and probiotics every day? Yes, you can, but these unique supplements have potential side effects and interactions. Here are some you should know:
- Bloating and Gas: Prebiotics may cause an abrupt increase in fiber, resulting in bloating and gas.
- Infections: Very rare, but for those with a weaker immune system, there's a slight risk that the live bacteria in probiotics can cause infections.
- Allergic Reactions: Some probiotic or prebiotic supplements could provoke allergies due to other components.
Conclusion
Combining probiotics and prebiotics can help maintain a healthy digestive system by contributing to a balanced digestion. Prebiotics and probiotics differ primarily because the former nourishes the good bacteria already in your stomach.
In contrast, the latter are live good bacteria that support the balance of your gut flora. Although fruits, vegetables, and whole grains can provide these nutrients, you can also take probiotics and prebiotics as supplements.
Additionally, remember that moderation is essential. Many of the negative effects related to prebiotics and probiotics are due to the fact that individuals with medical conditions are taking them without a doctor's approval or ingesting more than the recommended dosage of the product allows.
Take it slow at first and observe how the body responds. Following the plan and paying attention to the body's reaction will help to use them appropriately, without any trouble.
Learn More About Prebiotics and Probiotics:
Why trust our experts?
See Our Editorial Policy > Meet Our Health Expert NetworkThe WOWMD Staff category features a diverse team of writers, each bringing specialized knowledge in areas such as nutrition, fitness, wellness, and more. Articles in this category benefit from insights provided by multiple experts. All content is peer-reviewed and regularly updated to ensure compliance with our editorial standards.
Our Top Picks
Colon Sweep
Promotes natural detoxification, cleanses the colon, and boosts overall gut wellness.4.6 / 5.0
(534)534 total reviews
Colon Sweep
Greens Blend
Promotes immune strength, improves daily vitality, and nourishes overall well-being4.7 / 5.0
(769)769 total reviews
Greens Blend
Neuro Plus Brain & Focus Formula
Supports healthy cognitive wellness, everyday focus, and mental clarity.*4.7 / 5.0
(536)536 total reviews
Neuro Plus Brain & Focus Formula
SUBSCRIBE & SAVE UP TO 30%
Subscribe to your favorites WOWMD® supplements and enjoy flexible deliveries, easy account control, and savings on select products. FREE U.S. SHIPPING on orders over $60!
Shop Subscribe & Save
References
WOWMD follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, qualified experts, and information from top institutions.
References
- What doctors wish patients knew about improving gut healthhttps://www.ama-assn.org/delivering-care/public-health/what-doctors-wish-patients-knew-about-improving-gut-health
- The promotion mechanism of prebiotics for probiotics: A reviewhttps://pmc.ncbi.nlm.nih.gov/articles/PMC9581195/
- Can prebiotics and probiotics improve therapeutic outcomes for undernourished individuals?https://pmc.ncbi.nlm.nih.gov/articles/PMC4049942/
- Impacts of Gut Bacteria on Human Health and Diseaseshttps://pmc.ncbi.nlm.nih.gov/articles/PMC4425030/
- Effects of High-Fiber Diets and Macronutrient Substitution on Bloating: Findings From the OmniHeart Trialhttps://pmc.ncbi.nlm.nih.gov/articles/PMC7056053/
- Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergyhttps://pmc.ncbi.nlm.nih.gov/articles/PMC9919562/
Evidence Based Research
This WOWMD content has been reviewed, as well as checked for facts, so as to guarantee the best possible accuracy.
We follow a strict editorial policy, especially related to the sources we use. Our articles are resourced from reputable online pages, with research drawn from academic institutions and peer-reviewed studies. You can click on the numbers in the parentheses (1, 2, etc.) and check out those references.
The feedback form on this page can be used to report content that is not accurate, up-to-date or questionable in any manner.
We do NOT intend for the information presented through our articles to replace the medical relationship with a qualified physician, nor does it represent specialized advice.










