8 Best Supplements to Lower Cortisol & Manage Stress in 2026
Explore the best cortisol-reducing supplements with evidence-backed ingredients & adaptogens. Trusted by users for stress relief, enhanced energy, and overall well-being.
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Table of contents
- What is Cortisol?
- What Causes High Cortisol
- Our Top Picks
- Comparison Table
- What to Look for in Cortisol-Reducing Supplements?
- Top Ingredients
- Are Cortisol Supplements Safe?
- How Long Do Cortisol Supplements Take?
- Lifestyle Add-ons
- Signs Your Cortisol Is Back in Balance
- Conclusion
- FAQs
- Why Trust WOWMD?
- Meet the Experts

Wake up exhausted? Feel wired by noon, then crash by evening? You're likely dealing with elevated cortisol, the stress hormone that's supposed to protect you but instead is sabotaging your sleep, weight, and energy when it stays chronically high.
The good news: you don't need to accept this as your reality. Evidence-based supplements like ashwagandha and magnesium can naturally lower cortisol and restore your body's balance.
In this article, you'll discover the most effective cortisol-lowering supplements backed by science, and learn exactly how to use them to reclaim your energy and feel like yourself again.
TL;DR
- Cortisol is the body's stress hormone, but when it stays high, it can lead to fatigue, weight gain, and poor sleep.
- Top Pick: WOWMD Ashwagandha Extra Strength, best for stress relief & cortisol regulation.
- Key Benefits: Improved energy, better mood, enhanced focus, and balanced cortisol levels.
- Time to See Results: 2-4 weeks for best results with consistent use.
- Pro Tip: Combine supplements with stress management techniques (such as exercise, mindfulness, and quality sleep) for optimal results.
What is Cortisol?
Cortisol, often called the ‘stress hormone’, is produced by your adrenal glands and plays a vital role in your body’s response to stress.[1] It helps regulate energy by releasing glucose, supports your immune system, and manages inflammation.
Dr. Jason Winkelmann, Naturopathic Doctor, says;
Cortisol isn’t the enemy; it’s the body’s survival hormone. Problems arise when stress becomes chronic and the cortisol spike stays elevated, leading to fatigue, weight gain, inflammation, and hormone imbalance. The goal isn’t to suppress cortisol, but to restore its healthy rhythm.
In short bursts, cortisol is essential for survival, enabling your body to handle immediate challenges. However, when cortisol levels remain elevated due to chronic stress, it can lead to serious health issues.
💡 Did You Know? Cortisol peaks 30 to 40 minutes after waking up and drops throughout the day.
What Causes High Cortisol & What It Does to Your Body?
“In healthy individuals, cortisol peaks in the morning to help you wake up and gradually tapers through the day. However, cortisol can stay elevated throughout the day due to chronic stress, sleep deprivation, or inflammation,” says Dr. Jason Winkelmann
This elevated cortisol may cause:
- Sleep disruption: High cortisol keeps your mind racing at night, making it impossible to fall or stay asleep.
- Stubborn weight gain: Cortisol stores fat around your midsection and triggers cravings for sugar and comfort foods.
- Energy crashes: That wired-but-tired feeling that leaves you exhausted yet unable to relax.
- Mood swings and anxiety: You're irritable, on edge, and overwhelmed by everyday stressors.
- Weakened immunity: A suppressed immune system makes you more prone to colds and infections.
- Brain fog: Impaired memory and concentration that makes focusing nearly impossible.
- Hormonal imbalances: Disrupts thyroid function, sex hormones, and blood sugar regulation.
The good news is that lifestyle changes and natural cortisol reducers, such as adaptogens like ashwagandha and supplements for anxiety and stress, can help normalize cortisol levels.
Incorporating the best supplements to reduce cortisol into your routine, alongside stress management techniques, can restore balance and improve your overall health.
Best Supplements to Lower Cortisol
Best for Stress Relief & Mental Clarity: Ashwagandha Extra Strength Formula
Best for Daily Energy & Vitality: Greens Blend
Best for Relaxation & Emotional Balance: Anxiety Shield
Best For Relaxation & Sleep: Magnesium Glycinate
Best for Cognitive Support & Mental Clarity: Flawless Bloom CogniUltra
Best Cortisol Blocker: Primegenix CortiSync
Best for Cortisol Regulation & Sleep Support: Integrative Therapeutics - Cortisol Manager
Best for Cortisol & Belly Fat: Relacore Extra
01
Best for Stress Relief & Mental Clarity
Ashwagandha Extra Strength Formula
Pros
- Organic and non-GMO
- Third-party tested & GMP certified
- Includes black pepper for better absorption
- Supports stress relief and cognitive function
- Vegan-friendly & gluten-free
Cons
- May cause mild digestive discomfort
- Not suitable for pregnant or nursing individuals
Form: Capsule | Dosage: 1 capsule twice daily | Servings per container: 60 | Price: $57.60 (30-day supply) | Third-party tested: Yes | Customer Rating: 4.8
How it Helps:
This high-potency adaptogen combines organic ashwagandha root with black pepper extract to enhance absorption. It’s designed to regulate cortisol levels, improve mood, and support overall well-being.
“Ashwagandha shows the strongest evidence for lowering levels of cortisol and improving emotional resilience” says Edmond Hakimi, DO, FASAM.
Made in the USA in an FDA-registered facility, WOWMD Ashwagandha is ideal for those seeking natural cortisol reducers and supplements for stress and anxiety.
Things to Consider:
Consult a healthcare provider if you’re on medications or have medical conditions. Consistent use for 60–90 days yields the best results.
Consumer Experience:
I've been taking this Ashwagandha for a couple of weeks, and I feel more relaxed at work. It really helps manage my stress. -Charles S. ★★★★☆
Pros
- Combines adaptogens and superfoods
- Supports digestion and detoxification
- Boosts energy and endurance
- Non-GMO, vegan and gluten-free
- Third-party tested & GMP certified
Cons
- Taste may not appeal to everyone
Form: Powder | Dosage: 1 scoop (5.4g) daily | Servings per bottle: 28 | Price: $53.10 (1-month supply) | Third-party tested: Yes | Customer Rating: 4.8
How it Helps:
Greens Blend is a nutrient-dense superfood powder that combines organic greens, fruits, and adaptogens like ashwagandha. It’s designed to reduce stress, enhance energy, and help with digestion.
Made in the USA in an FDA-registered facility, this blend is ideal for those seeking natural cortisol reducers and overall vitality.
Things to Consider:
Consult a healthcare provider if you’re pregnant, nursing, or on medications. Consistent use for 60–90 days is recommended for optimal results.
Consumer Experience:
WOWMD Greens Blend is a solid choice for those looking to boost their nutrition with a daily greens powder. Its combination of greens, adaptogens, and probiotics makes it a well-rounded option for energy, digestion, and overall wellness. While the taste might require some getting used to, it's worth considering if you're looking for a nutrient-dense greens blend. -MH, Verified buyer ★★★★★
Pros
- Contains adaptogenic herbs like Ashwagandha and Rhodiola
- Promotes relaxation and emotional balance
- Enhances mental clarity and focus
- Non-GMO, vegan and gluten-free
- Third-party tested & GMP certified
Cons
- May interact with certain medications
- Not suitable for children under 18
Form: Capsule | Dosage: 2 capsules daily | Servings per container: 30 | Price: $55.80 (1-month supply) | Third-party tested: Yes | Customer Rating: 4.8
How it Helps:
WOWMD Anxiety Shield is a supplement made in the USA to reduce stress and anxiety while supporting mental clarity and emotional balance. Manufactured in an FDA-registered facility with a blend of adaptogen herbs, amino acids, and vitamins, it helps regulate cortisol levels and promotes relaxation naturally.
Things to Consider:
Consult a healthcare provider if you’re on medications or managing a medical condition. Consistent use for 60–90 days is recommended for optimal results.
Consumer Experience:
This is the second time that I bought this product, and I love it. It really helps me manage my stress, keeping me feeling relaxed and calm. I recommend it. -George R. ★★★★☆
Pros
- Highly bioavailable magnesium glycinate
- Supports muscle relaxation, heart health, and stress reduction
- Enhances energy production and bone density
- Non-GMO, Vegan, Gluten-Free
- Third-party tested & GMP certified
Cons
- May interact with certain medications
- Consult a healthcare provider if you are pregnant, nursing, or have a medical condition
Form: Capsule | Dosage: 3 capsules daily | Servings per container: 30 | Price: $60.30 (1-month supply) | Third-party tested: Yes | Customer Rating: 4.8
How it Helps:
Magnesium plays a key role in balancing the body's stress hormones and promoting relaxation. “Magnesium (especially glycinate or threonate) deficiency is linked to higher cortisol and anxiety. Replenishing magnesium helps the nervous system shift from “fight or flight” to “rest and digest,” says Dr. Jason Winkelmann.
WOWMD Magnesium Glycinate supports mental calmness, aids muscle recovery, and improves sleep quality, making it an essential tool for stress and anxiety relief.
Things to Consider:
Consult a healthcare provider if you are taking medications or managing a medical condition, especially regarding cortisol management.
Consumer Experience:
Magnesium Glycinate helps me unwind and relax my muscles. It’s become part of my nightly routine for stress relief. Works better than expected! -Derek C. ★★★★☆
Pros
- Features scientifically-backed ingredients like DMAE and L-Glutamine
- Enhances focus, clarity, and memory
- Supports mood balance and reduces mental fatigue
- Non-GMO, gluten-free, and no artificial additives
Cons
- May cause mild digestive discomfort in some users
- Not recommended for pregnant or nursing individuals
Form: Capsule | Dosage: 2 Capsule once a day | Servings per container: 30 | Price: $258.88 | Third-party tested: Yes| Customer Rating: 4.8
How it Helps:
CogniUltra is a cognitive formula that combines potent, natural nootropics and brain-boosting nutrients. It’s designed to support neurotransmitter balance, boost memory, and enhance focus.
Ideal for those seeking natural mental clarity and improved cognitive function
Things to Consider:
Consult with a healthcare provider if you’re on medications or have existing medical conditions.
Consumer Experience:
Cogniultra not only gives me mental clarity but also provides sustained energy throughout the day. No crashes, just consistent results! -Bianca B. ★★★★★
Pros
- Scientifically-backed ingredients
- Boosts exercise performance and helps manage stress
- Made with adaptogens like Sensoril® and Rhodiola
- Third-party tested and made in the USA
Cons
- Not suitable for children or pregnant women
Form: Capsule | Dosage: 2 capsules daily | Servings per container: 30 | Price: $59.00 (1-month supply) | Third-party tested: Yes | Customer Rating: 4.7
How it Helps:
CortiSync is a supplement designed to reduce elevated cortisol levels caused by stress, enhancing mental clarity, focus, and energy. The scientifically backed ingredients, including Sensoril® Ashwagandha, help lower cortisol levels, improve sleep, and reduce anxiety.
Things to Consider:
CortiSync is particularly effective for managing cortisol levels in active men over 30 dealing with fatigue, muscle fatigue, and stress.
Consumer Experience:
I am towards the end of my second bottle, and I love how much more I sleep at night, and I feel less anxious during the day. This may be a lifetime routine product for me. -Charles K. Orris ★★★★★
07
Best for Cortisol Regulation & Sleep Support
Integrative Therapeutics - Cortisol Manager
Pros
- Contains Sensoril® Ashwagandha for stress reduction
- Promotes restful sleep and relaxation
- Includes L-theanine and Magnolia for cortisol balance
- Gluten-free and vegan-friendly
Cons
- Contains soy (phosphatidylserine)
- May cause drowsiness if taken during the day
Form: Tablet | Dosage: 1 tablet before bedtime (increase to 2 during high stress)| Servings per container: 30 | Price: $25.75 (30 tablets) | Third-party tested: Yes | Customer Rating: 4.2
How it Helps:
Cortisol Manager is a clinically-backed supplement designed to support healthy cortisol levels and promote relaxation. With a blend of adaptogens like Sensoril® Ashwagandha and calming ingredients like L-theanine, it helps manage stress and improve sleep quality.
Things to Consider:
Consult a healthcare provider if pregnant, nursing, or on medications. Best taken in the evening to avoid daytime drowsiness.
Consumer Experience:
I have only been taking it for 2 weeks. Already feel the difference. Sleeping better, less tired in the morning, and stress reduced. I placed my re-order. -Amy, Amazon Buyer ★★★★★
Pros
- Targets stress-related belly fat
- Includes vitamins for immune support (Vitamin C, Zinc, B Complex)
- Reduces mild anxiety and stress
- Stimulant-free formula
Cons
- Requires 3 tablets daily
- Not suitable for individuals under 18
Form: Tablet | Dosage: 3 tablets daily | Servings per container: 30 | Price: $29.99 (1-month supply) | Third-party tested: N/A | Customer Rating: 4.2
How it Helps:
Relacore Extra is a stress-mitigating supplement designed to reduce stress-related belly fat while mproving mood and energy. Its proprietary blend includes adaptogens like Magnolia and Passionflower, along with essential vitamins and minerals for whole-body balance.
Things to Consider:
Best used alongside a healthy diet and exercise. Consult a healthcare provider if you have medical conditions or are on medications.
Consumer Experience:
Relatives always help the stress levels and cortisol in the belly. It takes time to see results 2 myths or more ,but it's lasting results. -FariChan, Amazon Buyer ★★★★★
Comparison Table
| Ashwagandha Extra Strength Formula | Greens Blend | Anxiety Shield | Magnesium Glycinate | Flawless Bloom CogniUltra | Primegenix CortiSync | Cortisol Manager | Relacore Extra | |
|---|---|---|---|---|---|---|---|---|
| Third-party tested | Yes | Yes | Yes | Yes | Yes | Yes | Yes | NA |
| Highlights | Organic, includes black pepper for absorption, supports stress relief | Combines adaptogens and superfoods, boosts energy, supports digestion | Adaptogenic herbs, promotes relaxation, enhances mental clarity | Magnesium Glycinate for muscle recovery, sleep quality, and managing stress | Enhances focus, clarity, and memory. | Helps reduce cortisol with Sensoril®, plus improves workout & performance | Sensoril® Ashwagandha, promotes restful sleep, balances cortisol | Targets stress-related belly fat, includes immune-supporting vitamins |
| Customer Rating | ||||||||
| Return Policy | 60-day money-back guarantee | 60-day money-back guarantee | 60-day money-back guarantee | 60-day money-back guarantee | 60-day money-back guarantee | 67-day money-back guarantee | NA | Free returns on U.S. orders |
| Shipping | Free US shipping | Free US shipping | Free US shipping | Free US shipping | Free US shipping | Free US shipping | Standard Charges | Standard Charges |
What to Look for in Good Cortisol-Reducing Supplements?
- Clinically studied ingredients: Choose supplements with standardized extracts and bioavailable forms that match those used in research studies.
- Effective dosages: The supplement should contain therapeutic amounts backed by science, not trace amounts that look good on a label.
- Third-party testing: Look for independent verification confirming purity, potency, and the absence of contaminants such as heavy metals or toxins.
- Clear label information: Transparent labeling that lists exact ingredient amounts, no proprietary blends hiding what you're actually getting.
- Brand reputation: Opt for supplements made in the USA from FDA-registered facilities that follow Good Manufacturing Practices (GMP).
- Allergen-free options: If you have sensitivities, choose products free of common allergens such as gluten, soy, and dairy.
- Positive reviews: Real customer feedback indicating the supplement actually works, not just marketing hype.
Top Ingredients to Look For (With Scientific Evidence)
Top Ingredients in Cortisol Reducing Supplements
Ashwagandha
Ashwagandha has been shown to reduce cortisol levels and alleviate stress.
A 2021 review of studies with 491 participants found that doses of 240-1,250 mg/day significantly lowered cortisol and stress[2]. One study showed 225 mg/day reduced saliva cortisol[2].
The studies were published in various clinical journals, and the systematic review was published in Frontiers in Pharmacology in 2021.
Phosphatidylserine
“Phosphatidylserine reduces cortisol spikes following intense exercise or mental stress, supporting recovery and cognitive clarity” explains Dr. Jason Winkelmann.
A study published in 2008 in the Journal of the International Society of Sports Nutrition found that taking 600 mg of phosphatidylserine (PS) daily for 10 days reduced cortisol levels by 39% compared to a placebo [3].
Magnesium
A study in Magnesium in the Central Nervous System (published on NCBI Bookshelf) explores the link between magnesium and stress, specifically its impact on cortisol secretion.
Magnesium interacts with the hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol. Research shows that magnesium deficiency can increase cortisol production and worsen stress responses.[4]
By stabilizing corticotropin-releasing factor (CRF) receptors and modulating neurotransmitters, magnesium helps lower stress hormone levels[4].
Rhodiola Rosea
Rhodiola rosea (R. rosea) is an adaptogen known to reduce stress. Clinical studies show it improves mental performance, physical endurance, and decreases perceived stress, with some trials reporting lower cortisol levels.
A 2022 study in Molecules found R. rosea reduced cortisol response after awakening in 60 patients with burnout[5].
Another trial showed it alleviated fatigue and improved quality of life, with noticeable benefits after 4 weeks of use[5].
“Rhodiola rosea improves stress resilience, energy, and mood by regulating the hypothalamic-pituitary-adrenal (HPA) axis,” adds Dr. Jason Winkelmann.
L-Theanine
L-theanine, an amino acid primarily found in green/black tea leaves and some mushrooms, promotes calm and relaxation without drowsiness.
A 2021 Neurology Therapy study found a single 200mg dose of AlphaWave® l-theanine significantly reduced salivary cortisol (p < 0.001) in healthy adults one hour after dosing, compared to placebo. [6]
Vitamin C
A 2024 study published in Stress Health explored how Vitamin C affects cortisol levels in women with chronic stress.
The study found that taking 1000 mg of Vitamin C daily for 2 months significantly lowered elevated cortisol and DHEA-S levels in participants.[7]
Cortisol dropped from 780 to 446 nmol/L in one group and from 657 to 515 nmol/L in another, suggesting Vitamin C's potential to manage stress-related hormone imbalances.[7]
Magnolia Bark Extract
“Magnolia Bark (Magnolia officinalis) contains honokiol and magnolol, compounds that calm the nervous system, reduce anxiety, and blunt cortisol surges without sedation,” says Dr. Jason Winkelmann.
A study published in the Journal of the International Society of Sports Nutrition in 2013 found that Magnolia bark extract (Relora®) reduced cortisol levels by 18% in moderately stressed individuals after 4 weeks.[8]
Are Cortisol Supplements Safe?
Cortisol-lowering supplements, including adaptogens like ashwagandha and Rhodiola rosea, are generally considered safe for short-term use when taken as directed.
“Safety concerns include mild digestive upset or interactions with thyroid, blood pressure, or sedative medications, so medical guidance before starting any supplement is advised,” says Dr. James Lyons.
However, mild side effects such as nausea, drowsiness, or digestive discomfort can occur, and certain supplements may interact with medications or affect conditions like thyroid function.
Long-term safety data are limited, so it’s essential to consult a healthcare provider before starting any regimen, especially if you’re pregnant, nursing, or managing chronic conditions. Choose high-quality, third-party-tested products.
“Patients on antihypertensives, SSRIs, or benzodiazepines should consult their clinician before starting any adaptogen regimen,” adds Dr. Jason Winkelmann.
How Long Do Cortisol Supplements Take to Work?
Most cortisol-lowering supplements take 2–8 weeks to show effects, but this depends on the ingredient, dose, baseline stress levels, and lifestyle.
Adaptogens for cortisol, like ashwagandha and Rhodiola rosea, often begin to reduce stress and cortisol levels within 2 to 4 weeks of consistent use[2][5].
Stress and anxiety supplements, such as L-theanine or magnesium, may offer quicker, short-term relief.
Lifestyle Add-ons to Lower Cortisol
- Exercise Regularly: Activities like yoga, walking, or moderate-intensity workouts help regulate cortisol by promoting relaxation and improving sleep quality.
- Adopt Foods to lower cortisol: Foods rich in magnesium, omega-3s, and antioxidants, such as leafy greens, dark chocolate, fatty fish, nuts, and berries, help lower stress. Fermented foods, bananas, eggs, and whole grains also support this.
- Practice Mindfulness: Techniques like meditation, deep breathing, or journaling are powerful natural cortisol reducers. These practices calm the HPA axis, helping you manage stress naturally.[9]
- Prioritize Sleep: Aim for 7–8 hours of quality sleep each night. A consistent sleep schedule and limiting caffeine can significantly reduce cortisol levels.
Dr. James Lyons adds, “Personally, I favor pairing a supplement with stress management techniques such as deep breathing, yoga, and healthy lifestyle habits to balance levels of cortisol for sustained well-being naturally.”
Natural Ways to Lower Cortisol
Signs Your Cortisol Is Back in Balance
When cortisol levels are balanced, you’ll notice improvements in both physical and mental well-being. Common signs include;
- Steady energy levels throughout the day
- Better sleep quality
- Reduced feelings of stress or anxiety.
Physically, you may experience;
- Stable blood pressure
- Improved digestion
- A stronger immune system
Mentally, balanced cortisol often leads to better focus, emotional stability, and an overall sense of calm. Combining cortisol-lowering supplement and lifestyle changes like mindfulness and exercise can help maintain this equilibrium.
Conclusion
Managing stress doesn’t have to feel overwhelming. In this guide, we’ve explored how cortisol impacts your body and how supplements can help you regain balance.
By combining the best supplements to reduce cortisol with lifestyle changes like mindfulness and quality sleep, you can regain control over your stress response. You’ll be waking up with calm, clarity, and energy—ready to tackle the day.
The right supplement stack can help you get there. Start small, stay consistent, and take the first step toward a healthier, more balanced you today. You’ve got this!
FAQs
Why Trust WOWMD?
WOWMD delivers unbiased, science-backed supplement recommendations through research and expert analysis. We evaluate products based on clinical evidence, ingredient quality, third-party testing, and honest consumer feedback, never compromising integrity for promotion.
Meet the Experts
- Dr. Jason Winkelmann, ND, DC, is a Naturopathic Doctor, Chiropractor & Chronic Pain Specialist at True Health Centers in the Denver Metropolitan Area
- Edmond Hakimi, DO, FASAM, is the Medical Director at Wellbridge in Calverton, New York, United States
- James Lyons is a Physician at LYONS MEDICAL CARE, PLLC in Austin, Texas, United States
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About WOWMD Staff
See Our Editorial Policy > Meet Our Health Expert NetworkThe WOWMD Staff category features a diverse team of writers, each bringing specialized knowledge in areas such as nutrition, fitness, wellness, and more. Articles in this category benefit from insights provided by multiple experts. All content is peer-reviewed and regularly updated to ensure compliance with our editorial standards.
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References
WOWMD follows strict sourcing guidelines to ensure the accuracy of its content, outlined in our editorial policy. We use only trustworthy sources, including peer-reviewed studies, qualified experts, and information from top institutions.
- Physiology, cortisol. StatPearls - NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK538239/
- Ashwagandha: Is it helpful for stress, anxiety, or sleep?: https://ods.od.nih.gov/factsheets/Ashwagandha-HealthProfessional/
- The effects of phosphatidylserine on endocrine response to moderate intensity exercise: https://pmc.ncbi.nlm.nih.gov/articles/PMC2503954/
- Magnesium and stress: https://www.ncbi.nlm.nih.gov/books/NBK507250/
- The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions—Encouraging Clinical Evidence: https://pmc.ncbi.nlm.nih.gov/articles/PMC9228580/
- A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave®l-Theanine on Stress in a Healthy Adult Population: https://pmc.ncbi.nlm.nih.gov/articles/PMC8475422/
- Vitamin C supplementation alleviates hypercortisolemia caused by chronic stress: https://pubmed.ncbi.nlm.nih.gov/38010274/
- Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects: https://pmc.ncbi.nlm.nih.gov/articles/PMC3750820/
- Physiology, Anterior Pituitary: https://www.ncbi.nlm.nih.gov/books/NBK499898/
- Obesity and Stress: A Contingent Paralysis: https://pmc.ncbi.nlm.nih.gov/articles/PMC9362746/
- Telogen Effluvium: https://www.ncbi.nlm.nih.gov/books/NBK430848/
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We follow a strict editorial policy, especially related to the sources we use. Our articles are resourced from reputable online pages, with research drawn from academic institutions and peer-reviewed studies. You can click on the numbers in the parentheses (1, 2, etc.) and check out those references.
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